What is AL Amyloidosis Market?
DelveInsight’s ‘AL Amyloidosis Market Insights,
Epidemiology, and Market Forecast—2032’ report deliver an in-depth
understanding of the AL Amyloidosis, historical and forecasted epidemiology as
well as the market trends in the United States, EU5 (Germany, Spain, Italy,
France, and United Kingdom), and Japan.
The AL Amyloidosis market report provides current treatment
practices, AL Amyloidosis emerging drugs, and their AL Amyloidosis market share
of the individual therapies, current and forecasted AL Amyloidosis symptoms market size from 2019 to 2032 segmented by seven major markets. The report also
covers current AL Amyloidosis symptoms treatment practice/algorithm and AL
Amyloidosis unmet medical needs to curate the best opportunities. It assesses
the underlying potential of the market.
It covers the details of conventional and current medical
therapies and diagnosis available in the AL Amyloidosis market to treat the
condition. It also provides the country-wise treatment guidelines and
algorithms across the United States, Europe, and Japan. The DelveInsight
AL Amyloidosis market report thoroughly understands AL Amyloidosis symptoms by
including disease definition, symptoms, causes, physiology, and diagnosis. It
also provides AL Amyloidosis treatment algorithms and treatment guidelines for
AL Amyloidosis symptoms in the US, Europe, and Japan.
Treatment for AL amyloidosis is highly individualized,
determined based on age, organ dysfunction, and regimen toxicities, and should
be guided by biomarkers of hematologic and cardiac response. Alkylator-based
chemotherapy is effective in almost two-thirds of patients; however, management
of AL Amyloidosis is challenging owing to the treatment-emergent side-effects.
Novel agents are also active, and trials are ongoing to establish their optimal
use.
Few major AL Amyloidosis unmet needs in the market include
lack of disease-specific curative therapies, high cost of approved therapies,
whereas the need for safer therapies with minimal toxicity profile, high disease,
and economic burden, and increasing incidence are driving opportunities in the
market.
AL Amyloidosis Emerging Drugs Profile
·
Daratumumab: Janssen Pharmaceutical/Genmab
Daratumumab (Darzalex Faspro) is an IgG1k monoclonal
antibody, first-CD38 directed targeted therapy, and binds to CD38.
Daratumumab binds to a different CD38 epitope amino-acid sequence than
causing cell apoptosis via antibody-dependent cellular cytotoxicity,
complement-dependent cytotoxicity, or antibody-dependent cellular phagocytosis.
These effects are dependent upon fragment crystallizable region immune effector
mechanisms. Antibody-dependent cellular cytotoxicity utilizes natural killer
cells.
In January 2021, Janssen Biotech announced that the Food and
Drug Administration granted accelerated approval to daratumumab plus
hyaluronidase in combination with bortezomib, cyclophosphamide, and
dexamethasone for newly diagnosed light chain (AL) amyloidosis. Janssen Biotech
announced updated positive results from the Phase III ANDROMEDA study, which is
evaluating daratumumab and hyaluronidase-fihj for the treatment of patients
with newly diagnosed light chain (AL) amyloidosis, a rare blood cell disorder
associated with the deterioration of vital organs, most notably the heart,
kidneys, and liver. Longer-term results from a median follow-up of 20.3 months
showed rates of hematologic complete response (hemCR) remained significantly
higher in patients treated with Darzalex Faspro in combination with bortezomib,
cyclophosphamide, and dexamethasone (D-VCd) compared to VCd alone.
·
Birtamimab: Prothena
Birtamimab, formerly known as NEOD001, is an investigational
monoclonal antibody designed to specifically and selectively target and clear
the amyloid that accumulates and causes organ dysfunction and failure in
patients with AL amyloidosis.
Birtamimab has been tested in nearly 300 patients with AL
amyloidosis at the intended clinical dose of 24 mg/kg and was shown to be
generally safe and well-tolerated in the clinical studies conducted to date.
Birtamimab was previously evaluated in Phase III VITAL Study, a global
multi-center, randomized, double-blind, placebo-controlled clinical study of
newly diagnosed, treatment naïve patients with AL amyloidosis and cardiac
involvement. Results from the analysis of patients categorized as Mayo Stage IV
at baseline in the VITAL study revealed a significant survival benefit favoring
birtamimab in these patients, with 74% of birtamimab-treated patients alive at
9 months versus 49% of patients in the control group.
The report’s AL Amyloidosis market outlook helps to better
understand the historic, current, and forecasted AL Amyloidosis market trends
by analyzing the impact of current therapies on the market, AL Amyloidosis
unmet needs, drivers and barriers, and demand for better technology. This
segment gives a thorough detail of AL Amyloidosis market trend of each marketed
drug and early-stage pipeline therapy by evaluating their impact based on the
annual cost of therapy, inclusion and exclusion criteria’s, mechanism of
action, compliance rate, growing need of the market, increasing patient pool,
covered patient segment, expected launch year, competition with other
therapies, brand value, their impact on the market and view of the key opinion
leaders.
The calculated market data are presented with relevant
tables and graphs to view the market at first sight. According to
DelveInsight, the AL Amyloidosis market in 7MM is expected to grow steadily
during the study period 2019–2032. Treatment for AL amyloidosis is highly
individualized, determined based on age, the severity of organ
damage/dysfunction, co-morbidities, and regimen toxicities, and should be
guided by biomarkers of hematologic and cardiac response.
Alkylator-based chemotherapy is effective in almost
two-thirds of patients. Novel agents are also active, and trials are ongoing to
establish their optimal use. Currently, the Bortezomib-based regimen
(CyBorD–cyclophosphamide, bortezomib, and dexamethasone) are currently used as
first-line therapy in AL amyloidosis. The CyBorD regimens are in wide use in
the US, EU, and Japan.
Oral melphalan 1 dexamethasone (MDex) has been a standard of care for many years in treating relapsing and refractory patients. Daratumumab plus hyaluronidase (Darzalex Faspro) in combination with bortezomib, cyclophosphamide, and dexamethasone has been granted accelerated approval, for newly diagnosed light chain (AL) amyloidosis, by US FDA, in January 2021. It is likely to become the next Standard of Care for AL Amyloidosis in the 7MM.
Source: AL Amyloidosis Market Forecast
DelveInsight’s ‘Canaloplasty -Market Insights, Competitive Landscape and Market Forecast – 2027’ report delivers an in-depth understanding of Canaloplasty and the history.
Familial Lipoprotein Lipase Deficiency Market
DelveInsight’s Familial Lipoprotein Lipase Deficiency Market Insights, Epidemiology and Market Forecast – 2032 report provides the detailed overview of the disease.
Healthcare Partner Indentification Services
DelveInsight’s ‘Heart Pump Device -Market Insights, Competitive Landscape and Market Forecast – 2027’ report delivers an in-depth understanding of Heart Pump Device.
Hydrocephalus Treatment Market
DelveInsight’s ‘Hydrocephalus Treatment -Market Insights, Competitive Landscape and Market Forecast – 2027’ report delivers an in-depth understanding of Hydrocephalus Treatment Market
DelveInsight’s Lactose Intolerance Market Insights, Epidemiology, and Market Forecast-2032″ report delivers an in-depth understanding of the Lactose Intolerance, historical and forecasted epidemiology as well as the Lactose Intolerance market trends in 7MM.
Meningococcal Meningitis Market
DelveInsight’s Meningococcal Meningitis Market Insights, Epidemiology and Market Forecast – 2032 report provides the detailed overview of the disease.
DelveInsight’s Penile Cancer Market Insights, Epidemiology, and Market Forecast-2032″ report delivers an in-depth understanding of Penile Cancer, historical and forecasted epidemiology.
Percutaneous Arterial Closure Device Market
Percutaneous Arterial Closure Device Market Research Report provides comprehensive insights into the Percutaneous Arterial Closure Device Market Size, Share, Key Companies
Persistent Epithelial Defect Market
DelveInsight’s Persistent Epithelial Defect (PEDs) Market Insights, Epidemiology, and Market Forecast-2032″ report delivers an in-depth understanding of the Persistent Epithelial Defect (PEDs), historical and forecasted epidemiology as well as the Persistent Epithelial Defect (PEDs) market trends in 7MM.
DelveInsight’s Sarcopenia Market Insights, Epidemiology, and Market Forecast-2032″ report delivers an in-depth understanding of the Sarcopenia, historical and forecasted epidemiology.
Scoliosis Market Insights, Epidemiology, Market Forecast report delivers an understanding of Scoliosis, historical and forecasted epidemiology as well as the Scoliosis market trends in 7MM.
Stem Cell Market Research Report provides comprehensive insights into the Stem Cell Market Size, Share, Key Companies, Competitive Analysis as well as the Market Forecast.
Technical Due Diligence | Technical Due Diligence Firms
Transient Ischemic Attack Market
DelveInsight’s Transient Ischemic Attack Market Insights, Epidemiology, and Market Forecast report delivers an in-depth understanding of the Transient Ischemic Attack forecasted epidemiology.
UK Healthcare Outlook Report | UK Healthcare Report
DelveInsight’s “UK Healthcare Outlook Report 2022,” provides comprehensive insights about the healthcare scenario, regulatory policies and reimbursement landscape in UK.
Related Report's Links
https://dating-making-friends.mn.co/posts/33727972
https://mydreamangels.mn.co/posts/33728010
https://network-96082.mn.co/posts/33728076
https://network-6342899.mn.co/posts/33728149
https://linkmate.mn.co/posts/33728162
https://network-1062788.mn.co/posts/33728527
https://d6united.mn.co/posts/33728572
https://wecanchat.mn.co/posts/33728600
https://networksbusiness.mn.co/posts/33728633
https://myparea.mn.co/posts/33728713
https://nordic-future.mn.co/posts/33621107
https://franko-trading-enterprise.mn.co/posts/33621345
https://the-trifecta-network.mn.co/posts/33621386
https://lgbtq-youth-chat.mn.co/posts/33621433
https://gotech.mn.co/posts/33621436
https://sokomtaani.mn.co/posts/33621458
https://nishweb-members.mn.co/posts/33621470
https://diamond-members.mn.co/posts/33621871
https://network-45056.mn.co/posts/33621964
https://tonow.mn.co/posts/33621987
https://global-non-profit-network.mn.co/posts/33622026
https://docspace-startup-school.mn.co/posts/33622143
https://network-86301.mn.co/posts/33622189
https://jointsnmotion-hub.mn.co/posts/33622322
https://network-77917.mn.co/posts/33622377
https://nova-driving-school.mn.co/posts/33622419
https://andrew-brown.mn.co/spaces/9349802/feed
About Us
DelveInsight is a Business Consulting and Market research company, providing expert business solutions for the healthcare domain and offering quintessential advisory services in the areas of R&D, Strategy Formulation, Operations, Competitive Intelligence, Competitive Landscaping, and Mergers & Acquisitions.
Contact Us
Yash Bhardwaj
info@delveinsight.com
Comments
Post a Comment